| abstract |
Amide compounds of the general formula (I), pharmaceutically acceptable acid addition salts thereof, and pharmaceuticals containing the same as active ingredients:n n n n n n n n Wherein R represents amino and the like, A represents alkylene and the like, X represents O, S and the like, M represents arylene and the like, and R 1 , R 2 , R 3 and R 4 are H, hydroxy And the like, R 5 represents H, alkyl and the like, m represents an integer of 0 to 6, R 6 represents optionally substituted aryl and the like, R 7 represents H, optionally substituted alkyl and the like. This amide compound has an excellent inhibitory effect on cytokines (IL-8, IL-1, IL-6, TNF-α, GM-CSF, etc.) directly or indirectly involved in inflammation, and arthritis due to rheumatic diseases It is useful for the prevention or treatment of diseases such as gout. |