| abstract |
Antiherpes nucleosides exhibiting increased activity against natural strains of the herpes virus, such as acyclovir monophosphate, acyclovir diphosphate and acyclovir triphosphate, as well as resistant strains, particularly thymidine kinase negative strains. Topical compositions for use in herpes virus infection comprising homologue phosphate esters. Antiherpes nucleoside homolog phosphate esters include phosphoramidates and phosphothioates as well as polyphosphates comprising C and S crosslinking atoms. |