| abstract |
The invention provides a topical topic of hyperproliferative diseases of the skin, including psoriasis, containing anti-proliferative nucleoside analogs, DNA chain terminating dideoxynucleoside analogs and mono-, di- and triphosphate esters of other nucleoside analogs. The present invention relates to a therapeutic pharmaceutical composition. Useful phosphate esters of nucleoside homologs include phosphoramidates and phosphothioates, and polyphosphates with C and S crosslinking atoms. |