http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990007987-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1996-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990007987-A |
| titleOfInvention | Quinazoline derivatives |
| abstract | The present invention relates to a quinazoline derivative of formula (1), or a pharmaceutically acceptable salt thereof:n n n Formula 1n n n n n n n n Wherein n is 1, 2 or 3, and each R 2 is halogeno, trifluoromethyl or (C 1 -C 4 ) alkyl, respectively; R 3 is (C 1 -C 4 ) alkoxy; And R 1 is di-[(C 1 -C 4 ) alkyl] amino- (C 2 -C 4 ) alkoxy, pyrrolidin-1-yl- (C 2 -C 4 ) alkoxy, pyridino- (C 2 -C 4 ) alkoxy, morpholino- (C 2 -C 4 ) alkoxy, pyrerazin-1-yl- (C 2 -C 4 ) alkoxy, 4- (C 1 -C 4 ) alkylpiperazin-1 -Yl- (C 2 -C 4 ) alkoxy, imidazol-1-yl- (C 2 -C 4 ) alkoxy, di-[(C 1 -C 4 ) alkoxy- (C 2 -C 4 ) alkoxy] amino -(C 2 -C 4 ) alkoxy, thiamorpholino- (C 2 -C 4 ) alkoxy, 1-oxothiamorpholino- (C 2 -C 4 ) alkyl or 1,1-dioxothiamorpholi Any R 1 substituent that is a no- (C 2 -C 4 ) alkoxy and includes a CH 2 (methylene) group that is not bonded to the N or O atom optionally has a hydroxy substituent on the CH 2 group.n n n The present invention also relates to methods of preparing quinazoline derivatives, and methods of using the receptor tyrosine kinase inhibitory properties of pharmaceutical compositions and compounds comprising the same for the treatment of proliferative diseases such as cancer. |
| priorityDate | 1995-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 377.