http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990006283-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 1997-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990006283-A |
| titleOfInvention | Method for preparing CDNA and recombinant LKN-3 of human isolated C6 β-chemokine LKN-3 (Leukotactin-3) |
| abstract | The present invention uses a cDNA encoding a novel protein (leukotactin-3: Lkn-3) belonging to C6β-chemokine, isolated from human monohomotic cell line (mohocytic cell line), using an expression vector comprising the same, an electric expression vector The present invention relates to a method for producing an electrical protein that attracts subsets of peripheral blood leukocytes. The open reading frame of Lkn-3 cDNA of the present invention encodes a total of 120 amino acids including a signal peptide consisting of 21 amino acids and a mature protein consisting of 99 amino acids. Recombinant Lkn-3, which was purely isolated by expressing the aforementioned Lkn-3 cDNA in recombinant E. coli or insect cells, significantly inhibits colony formation, has chemotaxis that attracts lymphocytes, monocytes and neutrophils, and binds hMIP-1α and RANTES. Has been shown to bind to the receptor of CCR1. The recombinant Lkn-3 protein can be used for antibody production, treatment during HIV-1 infection, bone marrow hepatocyte protection during chemotherapy or radiation therapy, leukemia inhibitor, and the like. |
| priorityDate | 1997-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 241.