| abstract |
R is a hydrogen atom or a carboxy, alkoxycarbonyl, -CO-NR 4 R 5 , -PO 3 H 2 or -CH 2 OH radical, R 1 is -alk-NH 2 , -alk-NH-CO-R 3 , -Alk-COOR 4 , -alk-CO-NR 5 R 6 or -CO-NH-R 7 radical.n n n Formula 1n n n n n n n n The compound of formula 1 is an antagonist of the α-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA) receptor, which has valuable pharmacological properties and is also known as a cusqualate receptor. In addition, the compound of formula 1 is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and more particularly the ligand for the NMDA receptor glycine modulator site. |