http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19980703450-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4166 |
| filingDate | 1996-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19980703450-A |
| titleOfInvention | 1,3-dihydro-1- (phenylalkenyl) -2H-imidazol-2-one derivative with PDE IV and cytokine inhibitory activity |
| abstract | The present invention relates to compounds having the structure of the general formula (I) having PDE IV and cytokine inhibitory activity, N-oxides thereof, pharmaceutically acceptable acid or base addition salts and stereochemical isomers:n n n n n n n n Wheren n n R 1 and R 2 are each independently hydrogen; C 1-6 alkyl; Difluoromethyl; Trifluoromethyl; C 3-6 cycloalkyl; Saturated 5-, 6- or 7-membered heterocycles having one or two hetero atoms selected from oxygen, sulfur and nitrogen; Indanyl; Bicyclo [2.2.1] -2-heptenyl; Bicyclo [2.2.1] heptanyl; C 1-6 alkylsulfonyl; Arylsulfonyl; Or substituted C 1-10 alkyl,n n n R 3 is hydrogen, halo or C 1-6 alkyloxy,n n n R 4 is hydrogen; Cyano; Optionally substituted C 1-6 alkyl; C 1-6 alkyloxycarbonyl or aryl, R 5 is hydrogen; Cyano; Optionally substituted C 1-6 alkyl; C 1-6 alkyloxycarbonyl or aryl,n n n Y is direct or C 1-3 alkanediyl,n n n -AB- is a divalent radical of the formula -CR 6 = CR 7 -or -CHR 6 -CHR 7- ,n n n L is hydrogen; Optionally substituted C 1-6 alkyl; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; C 1-6 alkylsulfonyl or arylsulfonyl,n n n Aryl is optionally substituted phenyl,n n n Het is morpholinyl or optionally substituted -piperidinyl; Piperazinyl; -Pyridinyl; Furanyl; Or thienyl.n n n The present invention also describes pharmaceutical compositions, methods of preparation and their use as medicaments. |
| priorityDate | 1995-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 363.