http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19980703449-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 1996-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19980703449-A |
| titleOfInvention | 1,3-dihydro-1- (phenylalkyl) -2H-imidazol-2-one derivative with PDE IV and cytokine inhibitory activity |
| abstract | The present invention is a disease state associated with abnormal enzymatic or catalytic activity of phosphodiesterase IV, and / or disease state involving cytokines excessively physiologically detrimental, in particular allergic, atopic and inflammatory diseases The present invention relates to a compound having the structure of the following general formula (I), a N-oxide thereof, a pharmaceutically acceptable acid or base addition salt and a stereochemical isomer thereof for the manufacture of a medicament for the treatment of warm-blooded animals.n n n n n n n n Wheren n n R 1 and R 2 are each independently hydrogen; C 1-6 alkyl; Difluoromethyl; Trifluoromethyl; C 3-6 cycloalkyl; Saturated 5-, 6- or 7-membered heterocycles having one or two hetero atoms selected from oxygen, sulfur and nitrogen; Indinyl; Bicyclo [2.2.1] -2-heptenyl; Bicyclo [2.2.1] heptanyl; C 1-6 alkylsulfonyl; Arylsulfonyl; Or substituted C 1-10 alkyl,n n n R 3 is hydrogen, halo or C 1-6 alkyloxyn n n R 4 is hydrogen; Halo; Optionally substituted C 1-6 alkyl; Trifluoromethyl; C 3-6 cycloalkyl; Carboxyl; C 1-4 alkyloxycarbonyl; C 3-6 cycloalkylaminocarbonyl; Aryl; Het 1, orn n n R 4 is a radical of the formula -OR 6 or -NH-R 7 ,n n n R 5 is hydrogen, halo, hydroxy or C 1-6 alkyl, orn n n (8 R), -CH 2 --CH 2 -N - - R 4 and R 5 of the general formula with - (CH 2) n-, -CH 2 -CH 2 -O-CH 2 --CH 2 CH Divalent radicals of 2 —CH 2 —, or —CH 2 —CH═CH—CH 2 — may form radicals,n n n Y is a direct bond, halo C 1-4 alkanediyl or C 1-4 alkanediyl,n n n -AB- is a divalent radical of the formula -CR 9 = CR 10 -or -CHR 9 -CHR 10- ,n n n L is hydrogen; Optionally substituted C 1-6 alkyl; C 1-6 alkylcarbonyl; C 1-6 alkyloxycarbonyl; Optionally substituted C 3-6 alkenyl; Optionally substituted piperidinyl; C 1-6 alkylsulfonyl or arylsulfonyl,n n n Aryl is optionally substituted phenyl,n n n Het 1 is morpholinyl, optionally substituted pyridinyl, -furanyl, -thienyl, -hydroxypyridinyl, -imidazolyl, -thiazolyl, -oxazolyl, -isoquinolinyl, -quinolinonyl , -Piperidinyl or -piperazinyl,n n n Het 2 is morpholinyl or optionally substituted piperidinyl, -pyrazinyl, -pyridinyl, -furanyl, -thienyl or -thienyl.n n n The present invention also relates to novel compounds having PDE IV and cytokine inhibitory activity, methods for their preparation and compositions containing these novel compounds. |
| priorityDate | 1995-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 447.