| abstract |
The present invention relates to a thiazole derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof.n n n Formula In n n n n n n n In the above formula, Ar 1 represents a substituted or unsubstituted phenyl group or thienyl group, Y 1 and Y 2 represent a nitrogen atom or a sulfur atom different from each other, R 1 represents a hydrogen atom, a C 1 -C 5 alkyl group, a phenyl group, Or an amino group which is unsubstituted or mono- or di-substituted with a C 1 -C 5 alkyl group, and R 2 represents a substituted or unsubstituted nitrogen heterocyclic group.n n n Compounds of the present invention are dopamine D 4 receptor antagonists that have antipsychotic effects without extraneous injuries. |