http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19980084683-A
Outgoing Links
| Predicate | Object |
|---|---|
| filingDate | 1997-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19980084683-A |
| titleOfInvention | Cancer cell killing method using specific promoter and gene (Ⅲ) |
| abstract | The present invention expresses thymidine kinase (TK) of Herpes Simplex Virus (HSV) using a specific promoter that is uniquely expressed only in specific cancer cells, and then the phosphorylated TK phosphorylates Gancyclovir to synthesize DNA of cells. It can inhibit cancer cells by killing them, or by introducing genes that induce apoptosis, they are expressed only in cancer cells without affecting other normal cells, resulting in apoptosis by killing cancer cells without affecting other normal cells. It is done.n n n Specific promoters include prostate-specific antigen (PSA), vascular endothelial growth factor (VEGF), chorionic gonadotropin (hCG), carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), and the gene of the expressed protein is herpes simplex virus (HSV). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), such as thymidine kinase (TK) gene, or interleukin-1 (IL-1) β converting enzyme (ICE) and ICE analogues (ICH-2, TX) . |
| priorityDate | 1997-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 389.