http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19980084682-A
Outgoing Links
| Predicate | Object |
|---|---|
| filingDate | 1997-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19980084682-A |
| titleOfInvention | Cancer cell killing method using specific promoter and gene (Ⅱ) |
| abstract | According to the present invention, after expression of thymidine kinase (tk) of Herpes Simplex Virus (HSV) using a specific promoter that is uniquely expressed in specific cancer cells, the tk is phosphorylated by phosphorylating Gancyclovir to inhibit DNA synthesis of cells. It may kill cancer cells or introduce a gene that induces apoptosis by the action of a promoter that is specifically expressed in cancer cells without affecting other normal cells. .n n n Specific promoters include prostate-specific antigen (PSA), vascular endothelial growth factor (VEGF), chorionic gonardotropin (hCG), carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), and the gene of the expressed protein is herpes simplex virus (HSV). Tumor necrois factor-related apoptosis-inducing ligand (TRAIL) such as thymidine kinase (TK) gene, or interleukin-1 (IL-1) β converting enzyme (ICE), ICE analogues (ICH-2, TX) . |
| priorityDate | 1997-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 401.