http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19980042860-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 1997-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19980042860-A |
| titleOfInvention | Method for preparing cDNA and recombinant Lkn-2 of C 6 β-chemokine Lkn-2 (Leukotactin-2) isolated from humans |
| abstract | The present invention utilizes a cDNA encoding a novel protein (leukotactin-2: Lkn-2) belonging to C6 β-chemokine, isolated from a human mononuclear cell line (monocytic cell line), an expression vector comprising the same, an electric expression vector The present invention relates to a method for producing an electrical protein that attracts subsets of peripheral blood leukocytes. The open reading frame of Lkn-2 cDNA of the present invention encodes a total of 137 amino acids, including a signal peptide consisting of 21 amino acids, of which the molecular weight of the mature protein consisting of 116 amino acids is estimated to be 12,500 Daltons. Recombinant Lkn-2, purified by expressing the aforementioned Lkn-2 cDNA in recombinant E. coli or insect cells, significantly inhibits colony formation, has chemotaxis that attracts lymphocytes, monocytes and neutrophils, and hMIP-1α and RANTES It has been shown to bind to the receptor of binding CCR1. The recombinant Lkn-2 protein can be used for antibody production, treatment during HIV-1 infection, bone marrow hepatocyte protection during chemotherapy or radiation therapy, leukemia inhibitor, and the like. |
| priorityDate | 1996-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 194.