http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19980042501-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7023 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 |
| filingDate | 1997-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19980042501-A |
| titleOfInvention | Methods and compositions for promoting skin penetration of drugs with penetration enhancers when drugs and / or penetration enhancers are unstable during long term combination storage |
| abstract | The present invention relates to a method for promoting epidermal, transdermal and dermal penetration of pharmaceutically active agents (such as drugs or agents) for topical administration which have a low skin penetration rate in the absence of a penetration enhancer and which are unstable during prolonged storage with certain penetration promoters and cause degradation. Provide means. In addition, according to the present invention there is also provided a method and means for increasing skin penetration of pharmaceutical actives which usually have poor skin penetration rates and which, when combined with prolonged skin penetration agents, destabilize and degrade the penetration promoter. According to the present invention, at least one first composition containing a drug, a pharmacologically acceptable salt thereof, a chemical derivative or a combination thereof in a dermatologically acceptable carrier and at least one second composition containing a penetration promoter in the acceptable carrier are provided. Is provided. These compositions are physically isolated from each other until topically applied to the body or skin surface simultaneously, or continuously, within a short period of time, mixed and preferably formed into the final active composition on the skin. It is also possible according to the invention to make premixes of these compositions and apply them to the skin. The drug can be delivered to the skin and systemic circulatory system in therapeutically effective amounts according to the present invention, and when used, it is possible to significantly increase the penetration rate of drugs with poor skin penetration, usually by the action of penetration promoters in the active composition. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11337745-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200112156-A |
| priorityDate | 1996-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 330.