| abstract |
The present invention is represented by the formula (1)n n n [Formula 1]n n n n n n n n [Wherein, R 1 and R 3 each represent a phenyl group which may have a substituent, R 2 represents a phenyl group or a cycloalkyl group which may have a substituent, and the broken line represents the bond state of either E or Z. Provided that when R 1 , R 2 and R 3 are unsubstituted phenyl groups, R 1 and R 2 are unsubstituted phenyl groups and R 3 is 4-ethoxyphenyl group. A salt thereof and a medicine containing the same as an active ingredient, and a method for preventing and treating atherosclerosis using the medicine. The derivative of the present invention or a salt thereof is useful as a prophylactic and therapeutic agent for atherosclerosis because it selectively and strongly inhibits ACAT in macrophages. |