| abstract |
The present invention relates to a composition for treating or preventing infectious gastritis caused by Helicobacter pylori infection, containing a steamed ginger extract as an active ingredient. The composition of the present invention does not show cytotoxicity up to a concentration of 200 μg / ml in AGS (human gastric adenocarcinoma cell) cell line, which is a Helicobacter pylori infection-induced gastritis model, and the inflammatory cytokines IL-8, TNF-α, IL-6, and IL -Effectively inhibits 1β gene expression, inhibits phosphorylation of p65 protein and IκBα protein involved in NF-κB signaling system, inhibits production of nitric oxide, and inhibits gene expression of iNOS gene involved in induction of inflammation and exhibits immunomodulatory activity through inhibition of IFN-γ gene expression and inhibition of MPO enzyme activity, and exhibits direct antibacterial activity against Helicobacter pylori strains, so that it can be effectively used for the treatment and prevention of bacterial gastritis symptoms caused by Helicobacter pylori strains. can |