| abstract |
The present invention belongs to the field of medicinal chemistry and relates to novel pyridone derivatives represented by formula (I) or stereoisomers, pharmaceutically acceptable salts, solvates or crystals thereof and influenza type A or/and influenza B It relates to applications for manufacturing drugs for preventing or treating viral infectious diseases such as influenza A or/and, more specifically, as PA subunit cap-dependent endonuclease inhibitors. It relates to applications for use in the prevention or treatment of influenza B viral infectious diseases. The compounds of the present invention have significant influenza endonuclease and influenza DNA inhibitory activity, either alone or as neuraminidase inhibitors, nucleoside drugs, PB2 inhibitors, PB1 inhibitors, M2 inhibitors or other anti-inflammatory drugs. It can be used in combination with influenza drugs, greatly shortens the time of influenza infection and lowers the mortality rate, so the prospect of clinical application is quite bright. (I) |