http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102471368-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2015-8518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67 |
| filingDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102471368-B1 |
| titleOfInvention | Sequence variants |
| abstract | Amino acid residue misincorporations are necessarily found in low-abundance sequence variants mixed with the expressed polypeptide, resulting from one or more base mismatches within codons that are susceptible to amino acid residue misincorporation during transcription and/or translation. The present invention provides a method for optimizing the coding sequence of a polynucleotide encoding a polypeptide wherein at least one codon is susceptible to amino acid residue misincorporation. The method of the present invention can be used to reverse engineer an unknown coding sequence that encodes the same polypeptide but differs from a known coding sequence at at least one codon above. Additionally, these methods can be used to alter the immunogenic potential of an expressed polypeptide. Thus, the present invention is useful for engineering optimized polynucleotides encoding polypeptides. |
| priorityDate | 2014-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 646.