Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2517-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate |
2015-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-102468108-B1 |
titleOfInvention |
Methods and compositions for targeted genetic modifications and methods of use |
abstract |
Methods and compositions for generating targeted genetic alterations on the Y chromosome or on a challenging target locus are provided. The composition comprises an in vitro culture comprising XY pluripotent and/or totipotent animal cells (ie, XY ES cells or XY iPS cells) having a modification that reduces the level and/or activity of Sry protein; culturing these cells in a medium that promotes the development of XY F0 fertile females. Such compositions find use in a variety of methods for producing fertile female XY non-human mammals of the F0 generation. |
priorityDate |
2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |