| abstract |
The present invention provides a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic agent, encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic polypeptide agent. nucleic acids and corresponding recombinant vectors and host cells comprising said nucleic acids and preferably expressing said fusion polypeptides. The present invention also provides a kit of parts comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally, at least one chemical agent for linking the fibronectin binding polypeptide (FnBP) to the diagnostic or therapeutic agent. parts). The present invention also relates to said compositions, nucleic acids, vectors, host cells and kits for use in the therapeutic or prophylactic treatment of diseases, preferably diseases associated with abnormal fibronectin accumulation, such as cancer, fibrosis or immune diseases. . |