| abstract |
The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutic agents and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, and directing cells to express proteins using the nucleic acids. It relates to methods, kits and devices for transfection, gene editing, and reprogramming of cells, and to cells, organisms, therapeutic agents, and cosmetics made using these methods, kits, and devices. Methods and products for modifying the DNA sequence of a cell, and methods and products for inducing a cell, including a cell in vivo, to express a protein using a synthetic RNA molecule are described. A therapeutic agent comprising a nucleic acid encoding a gene-editing protein is also described. |