http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102403818-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2529-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2020-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102403818-B1 |
| titleOfInvention | Nucleic acid nanostructures with aptamers, and 3D cell culture use thereof |
| abstract | The present invention relates to a nucleic acid nanostructure functionalized with an aptamer capable of specifically attaching to a target cell, and a three-dimensional cell culture use thereof. The three-dimensional cell culture model using the nucleic acid nanostructure to which the aptamer is bound according to the present invention is capable of culturing various cells targeting specific cells according to the aptamer sequence, compared to the case of using a conventional peptide having a cell adhesion function, etc. The same cell culture efficiency can be achieved using a very low concentration of aptamer compared to the prior art. In addition, the aptamer can be easily chemically synthesized and inexpensive, so it can secure high economic efficiency, and can be manufactured by introducing various biocompatible materials having a photocrosslinking functional group into the hydrogel, so that the material can be universally applied do. Moreover, the grafting of nucleic acid nanostructures and aptamers makes it possible to easily manipulate the size and shape of the structures in nano units, so that the functionality of the aptamers for cell culture in the hydrogel can be very precisely manipulated. Due to this, the nucleic acid nanostructure to which the aptamer is bound according to the present invention is expected to be usefully used for three-dimensional cell culture. |
| priorityDate | 2020-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.