| abstract |
The present invention provides a method for identifying compounds that prevent, ameliorate and/or inhibit hepatitis B virus (HBV) infection, the expression of PAP-associated domain containing 5 (PAPD5) and/or PAP-associated domain containing 7 (PAPD7) and/or reduce activity; (ii) a compound that binds to PAPD5 and/or PAPD7 and inhibits reproduction of HBV is identified as a compound that prevents and/or ameliorates and/or inhibits HBV infection. The present invention also provides an inhibitor of PAPD5 and/or PAPD7 for use in the treatment and/or prevention of HBV infection; and to a combination formulation for simultaneous or sequential use in the treatment or prevention of HBV infection, comprising an inhibitor of PAPD5 and an inhibitor of PAPD7. The present invention also relates to pharmaceutical compositions for use in the treatment and/or prophylaxis of HBV infection, and to methods of monitoring the success of treatment during treatment of HBV infection. |