| abstract |
The present invention suppresses NETosis induced by phorbol myristate acetate (PMA), CSE (cigarette smoke extract), PPE (porcine pancreas elastase), PM2.5 (ultra-fine dust with a diameter of 2.5 micrometers or less) Inhibits the expression of inflammatory cytokines IL-6 and IL-8 in H292 cells, a bronchial epithelial cell line stimulated by IL-8) as well as lowering the number of neutrophils in BALF in animal model experiments of COPD induced by CES and PPE, and MIP-2, TNF-α, IL-1β, IL- in BALF or lung tissue. 6, Disclosed a composition for improving asthma or chronic obstructive pulmonary disease using needle flower extract that lowers the concentration of inflammatory cytokines such as KC, MCP-1, and IFN-γ and lowers the concentration of other MDC, GM-CSF, IL-17, etc. do. |