| abstract |
A polypeptide comprising an antibody Fc region variant comprising an amino acid sequence in which the EU numbering 238th amino acid modification and other specific amino acid modifications are combined maintains binding activity to FcγRIIb as compared to a polypeptide containing an Fc region of native IgG It was found to reduce the binding activity to all active FcγR, especially FcγRIIa (R-type). |