abstract |
The present invention relates to the treatment of p38 kinase mediated diseases, such as auto-inflammatory diseases, including lymphoma and rheumatoid arthritis, having the structure of formula (I). useful methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds; a pharmaceutical composition comprising at least one of said compounds; and a method of treating a p38 kinase mediated disease using the compound: [Formula (I)] wherein R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the detailed description. |