| abstract |
The present invention discloses a composition for improving allergy, asthma or chronic obstructive pulmonary disease (COPD) using the extract of Saengyeolgwi tree. Saengyeolgwi tree extract inhibits netosis activation of neutrophil extracellular traps induced by PMA (phorbol myristate acetate), and inflammatory cytokines by CSE in NCI-H292 cells, a bronchial epithelial cell line. It suppresses the expression of IL-8, and also has the activity of inhibiting the expression of MIP-2, an inflammatory cytokine, in MH-S cells, which are alveolar macrophages activated by CES and LPS (lipopolysaccharide). In addition, the respiratory disease mouse model administered with the extract of Saengyeolgwi tree exhibits an activity of reducing the total number of BALF cells compared to the group administered with Roflumilast (ROF), a positive control. |