| abstract |
Provided is a genetically modified mouse, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, and wherein the mouse is a human immunoglobulin sequence operably linked with a mouse kappa (κ) constant gene at the endogenous mouse K locus. expressing only one or two human light chain variable domains expressed by Expresses a reverse chimeric antibody having a variable domain and a mouse heavy chain constant domain. A fully human bispecific epitope-binding protein is provided, comprising two different heavy chains associated with the same light chain comprising variable domains derived from one of two different human light chain variable region gene segments. |