| abstract |
According to the description and claims of the present application P 1 - P 12, T 1 and the general formula (I) is defined to be T 2: cyclo [P 1 -P 2 -P 3 -P 4 -P 5 -P 6 -P 7 -P 8 -P 9 -P 10 -P 11 -P 12 -T 1 -T 2 ] beta-hairpin peptide mimetics and pharmaceutically acceptable salts thereof, for example, Klebsiella pneumoniae, It has a broad spectrum of gram-negative antimicrobial activity in inhibiting the growth or killing of microorganisms such as Cinetobacter baumanii and/or Escherichia coli. These compounds can be used as medicaments to treat or prevent infections, or as bactericides for food, cosmetics, pharmaceuticals or other nutrient-containing substances. These peptidomimetics can be prepared by methods based on hybrid solid- and liquid-phase synthetic strategies. |