http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102278665-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00293 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-34 |
| filingDate | 2019-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102278665-B1 |
| titleOfInvention | Method of manufacturing collagen-coated synthetic bone graft with macro pores and synthetic bone graft manufactured thereby |
| abstract | The present invention relates to a method for manufacturing a synthetic bone graft material, and more particularly, to a method for manufacturing a synthetic bone graft material having macropores coated with collagen, the method comprising the steps of: (1) preparing a synthetic bone graft material having macropores; (2) preparing a stabilized collagen by physically crosslinking it so that it does not rapidly decompose or dissolve when implanted in vivo; and (3) coating each particle of the synthetic bone graft material prepared in step (1) with the collagen prepared in step (2). According to the method for producing a synthetic bone graft material having collagen-coated macropores and the synthetic bone graft material prepared by the method proposed in the present invention, by heat-treating synthetic bone particles and bead-shaped biopolymers of various sizes different from each other, the macropores are mixed and heat treated. By including the step of improving the strength of the synthetic bone graft material manufactured through the press compression method while manufacturing the formed synthetic bone graft material, a synthetic bone product having a higher porosity compared to the conventional product can be manufactured while still having weak strength By supplementing the loss of bone, it is possible to ultimately improve the bone formation performance. In addition, according to the method for manufacturing a synthetic bone graft material with collagen-coated macropores proposed in the present invention and the synthetic bone graft material prepared thereby, in order to overcome the inconvenience of operation, which is a disadvantage of the conventional powder-type bone graft material, collagen coating Since it is manufactured as a gel-type bone graft material through It also increases the stability of collagen, and it is possible to secure viscosity even with a small amount of collagen. In addition, according to the method for producing a synthetic bone graft material having macropores coated with collagen and the synthetic bone graft material prepared by the method proposed in the present invention, the synthetic bone graft material is treated with oxygen plasma to form a negative charge on the surface, and After forming a positive charge by adjusting the pH, the two are mixed and the surface of the synthetic bone graft material is atelocollagen-coated through an electrostatic method, thereby eliminating the side effects existing in the conventional coating method using chemical agents, and freeze-drying Collagen can be strongly coated on the surface of the synthetic bone graft material while removing moisture. |
| priorityDate | 2019-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.