http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102277871-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2835 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102277871-B1 |
| titleOfInvention | The collection method of diagnosis information of Parkinson's disease by assessment of the α-synuclein oligomers in the urine and the kit |
| abstract | α-Synuclein (α-Syn) is a major component of Lewy bodies, an important pathological marker of Parkinson's disease (PD). Attempts to use the difference in the amount of α-Syn present in biological fluids such as blood, saliva, and cerebrospinal fluid in PD patients and controls as a diagnostic marker for PD have been in progress for a long time, but the results of these studies were different and there were no practical results. Recently, there has been an attempt to quantify the polymer of α-Syn and use it as a biomarker. The present invention confirmed the presence of α-Syn in concentrated patient urine for the first time, and confirmed the immunoenzyme precipitation method (ELISA) using various α-Syn antibodies that recognize the polymer form of a specific α-Syn. As a result of quantification of specific α-Syn polymers in urine samples of PD patients and controls using this method, the α-syn polymer composed of β-sheet-rich in the urine of patients significantly increased, It was confirmed that the amount of α-syn polymer aggregated in a spherical shape was significantly reduced. In conclusion, it was confirmed that the amount of a specific α-Syn polymer in the urine sample showed a significant difference between the patient and non-patient control groups, and through this, the basis for developing a Parkinson's disease diagnostic kit was derived. |
| priorityDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.