| abstract |
The present invention provides an avian cell in which the expression or activity of one or more of the genes of chicken IFITM1 (SEQ ID NO: 1), chicken IFITM2 (SEQ ID NO: 2) and chicken IFITM3 (SEQ ID NO: 3), or a homologue thereof, is reduced. The present invention also provides a method of subculturing a virus in avian cells, embryos and/or avian cell lines with reduced expression of one or more IFITM genes, and chicken IFITM1 (SEQ ID NO: 1), chicken IFITM2 (SEQ ID NO: 2) and chicken IFITM3 (SEQ ID NO: 3) ) of one or more of the genes, or homologues thereof. |