| abstract |
The present invention inhibits NETosis induced by phorbol myristate acetate (PMA), and inhibits the expression of IL-8, an inflammatory cytokine, by H292 cells, a bronchial epithelial cell line stimulated by CSE (cigarette smoke extract). Inhibits the expression of the inflammatory cytokine MIP2 (IL-8) in MH-S cells, which are mouse alveolar macrophages activated by CES, as well as inhibits the activity of the proteolytic enzyme elastase, CES and PPE (porcine pancreas elastase)-induced COPD, lowered the number of neutrophils in BALF and the concentration of inflammatory cytokines such as MIP-2, TNF-α, IL-1β, and IL-6 in BALF or lung tissue Disclosed is a composition for improving chronic obstructive pulmonary disease using a Nahansong extract having lowering activity. |