abstract |
An object of the present invention is a method for promoting antigen-binding molecule-mediated antigen uptake into cells, a method for promoting a decrease in plasma antigen concentration, a method for increasing the number of antigens that a single antigen-binding molecule can bind to , a method of improving the pharmacokinetics of an antigen-binding molecule, an improved antigen-binding molecule for accelerated antigen uptake into cells, an antigen-binding molecule capable of promoting a decrease in the concentration of antigen in plasma, repeatedly binding to an antigen It is to provide an antigen-binding molecule capable of having an antigen-binding molecule with improved pharmacokinetics, a pharmaceutical composition comprising such an antigen-binding molecule, and a method for preparing the above. We found that antigen uptake into cells is facilitated by antibodies with human FcRn-binding activity at plasma pH and lower antigen-binding activity at initial endosomal pH than at plasma pH; Such antibodies can increase the number of antigens to which a single antigen-binding molecule can bind; Reduction of antigen in plasma can be promoted by administering such an antibody; It has been found that antibody pharmacokinetics can be improved by using such antibodies. |