abstract |
Providing an antibody targeting CAPRIN-1, superior in antitumor activity than a conventional antibody, and use as an agent for the treatment and/or prevention of cancer. The present invention provides an antibody targeting CAPRIN-1 polypeptide specifically expressed on the surface of cancer cells, and the use of the antibody as an agent for treating and/or preventing cancer. Including a heavy chain variable region comprising a complementarity determining region of SEQ ID NOs: 1, 2 and 3 and a light chain variable region comprising a complementarity determining region of SEQ ID NOs: 4, 5 and 6, and having immunological reactivity with CAPRIN-1 protein. It provides an antibody or a fragment thereof, and a pharmaceutical composition for the treatment and/or prevention of cancer comprising the antibody or fragment as an active ingredient. |