http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102252123-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-314 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2019-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102252123-B1 |
| titleOfInvention | Composition for improving respiratory diseases using the extract of Hydrangea serrata |
| abstract | The present invention discloses a composition for improving pulmonary diseases such as asthma or chronic obstructive pulmonary disease using a corn hydrangea extract. Cornus extract inhibits the activation of netosis of neutrophil extracellular traps induced by PMA (phorbol myristate acetate), and is an inflammatory cytokine caused by CSE in NCI-H292 cells, a bronchial epithelial cell line. It inhibits the expression of IL-8 and has the activity of inhibiting the expression of the inflammatory cytokine MIP-2 in alveolar macrophage MH-S cells activated by CES and LPS (lipopolysaccaride). In addition, in the respiratory disease mouse model to which the hydrangea extract was administered, the total number of BALF cells decreased more than the group to which Roflumilast (ROF), which was a positive control, was administered, and showed an activity of inhibiting the secretion of inflammatory cytokines and chemokines. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210085175-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102308618-B1 |
| priorityDate | 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 248.