http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102249040-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4704 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102249040-B1 |
| titleOfInvention | Amphiphysin-I mutant having anti-senescence activity and use thereof |
| abstract | The present invention relates to an ampicin-I mutant having anti-aging activity and a use thereof, and in particular, the present invention relates to the amino acid sequence of ampicin-I (amphiphysin-I; AMPH-I) represented by SEQ ID NO: 1. Ampicin-I mutant in which valine (V), which is the 392th amino acid in, is substituted with glycine (G), a composition for inhibiting cellular aging containing the mutant as an active ingredient, for preventing or treating aging or aging-related diseases It relates to a pharmaceutical composition, a method for inhibiting cellular senescence, and a method for screening an inhibitor of cellular senescence. The ampicin-I mutant according to the present invention can inhibit both promotion of cell aging and reduction of cell transduction by inhibiting the expression of βPIX (PAK1-interacting exchange factor beta), and protein in cell aging by inhibiting βPIX expression. The ampicin-I protein cleavage by calpain, a degrading enzyme, does not occur, and can inhibit the expression of cellular aging indicators, and the ampicin-I mutant of the present invention is a novel method for aging or aging-related diseases. There is an effect that can be used as a treatment. |
| priorityDate | 2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 656.