| abstract |
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula I and pharmaceutically acceptable salts thereof: <Formula I> (In the above formula, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b , R 5 , R 6 and R 7 are as defined herein). The compounds are used for the prevention and treatment of various CNS-related conditions, for example sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, memory and/or cognitive disorders, motor disorders, personality disorders, autism spectrum disorders, pain, traumatic It is useful for the treatment of brain injury, vascular disease, substance abuse disorder and/or withdrawal syndrome and tinnitus. |