http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102238179-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102238179-B1 |
| titleOfInvention | Simple manufacturing method of abibactam |
| abstract | The present invention relates to a simple preparation method of abibactam, and a condensation reaction with O-protected hydroxyamine hydrochloride using piperidin-5-one-2S-formate II as a raw material, and reduction, chiral separation and alkali Hydrolysis under conditions to obtain 5R-substituted oxyiminopiperidine-2S-formic acid V, through a one-pot reaction with phosgene, triphosgene or diphosgene, a cyclic urea reaction, an acyl chloride reaction, and Through amidation reaction, removal of the protecting group, sulfation reaction, and tetrabutyl ammonium salt formation reaction, {[(2S, 5R)-2-carbamoyl-7-oxo-1,6-diazacyclo[3.2.1 ]Octan-6-yl]oxy}sulfonyltetra-n-butylammonium salt VII was obtained, and finally, abibactam I was prepared through ion exchange. The present invention has a simple reaction path, easy operation, low cost of raw materials, low cost, low emission of "three wastes", high atomic utilization, excellent economical efficiency, and advantageous for environmental preservation, The yield of each reaction step is high, and it is advantageous for industrial production of abibactam. |
| priorityDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 212.