| abstract |
The present disclosure relates to a dimer of an engineered polypeptide having binding affinity for the neonatal Fc receptor FcRn, an FcRn binding dimer comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the agent Each of the first and second monomer units provides an FcRn binding dimer comprising an FcRn binding motif. The FcRn binding dimer binds to FcRn with a higher ability when compared to the first monomer unit or the second monomer unit alone. The present disclosure also relates to the use of such FcRn binding dimers as agents and as therapeutic agents for modifying pharmacokinetic and pharmacodynamic properties. |