| abstract |
The present invention provides an intermediate for preparing an atropisomer of a pyrrole derivative having an excellent mineralocorticoid receptor antagonism, a method for preparing it, and a crystal thereof. The following general formula (I), characterized by using an optically active amine having a cinconan skeleton [In the formula, R 1 represents a methyl group or a trifluoromethyl group, R 2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] A method for producing an atrop isomer of a pyrrole derivative containing, and (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-( Determination of trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide. |