abstract |
The present invention relates to a composition for preventing, improving or treating CD8 + memory T cell-mediated diseases, wherein the composition according to the present invention comprises CD69 + CD103 - CD8 + memory T among CD8 + memory T cells present in the liver. the cells are based on the group (Subpopulation) resident tissue, the CD69 + CD103 - CD8 + memory only T cells by inhibiting the expression level or activity of HIF-2α is present in high levels specifically CD69 + CD103 - CD8 + memory It can induce the death of T cells or effectively inhibit its function. Furthermore, through such an effect, it can be very usefully applied to the prevention, improvement or treatment of CD8 + memory T cell mediated diseases. |