http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102217785-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-328 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-326 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-35 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10 |
| filingDate | 2018-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102217785-B1 |
| titleOfInvention | Chronic stress-exposed animal model of diabetes mellitus characterized by overproduction of nitric oxide, vascular endothelial dysfunction and heat rate reduction, its manufacturing method and uses thereof |
| abstract | The present invention relates to a diabetic animal model exposed to chronic stress characterized by excessive production of nitric oxide in blood, vascular endothelial dysfunction, and heart rate reduction, a method of manufacturing the same, and a use thereof, and more specifically, simply without genetic mutation. The present invention relates to a diabetic animal model exposed to chronic stress, which can induce diabetes physiologically, and its phenotype is due to excessive production of nitric oxide in blood, vascular endothelial dysfunction, and decreased heart rate. The diabetic animal model according to the present invention exhibits a serum glucose concentration similar to that of the existing model, and the serum nitric oxide concentration has increased characteristics similar to those of clinical type 2 diabetic patients, as well as certain vascular endothelial dysfunction and heart rate. In addition to having a decrease, the time required to induce it has been drastically shortened. Therefore, the diabetic animal model exposed to chronic stress of the present invention is effective in the study of diabetes and excessive production of nitric oxide due to diabetes, vascular endothelial dysfunction and heart rate reduction. It is useful for mechanistic research or development of pharmaceuticals for prevention and treatment. In addition, the present invention relates to a pharmaceutical composition and a health functional food composition for improvement or treatment of excessive production of serum nitric oxide, vascular endothelial dysfunction, and heart rate reduction comprising linaryl acetate as an active ingredient. The composition according to the present invention has been found to have the effect of normalizing abnormally increased serum nitric oxide and vascular endothelial dysfunction.As a result, it is possible to improve or treat excessive production of serum nitric oxide, vascular endothelial dysfunction, and heart rate reduction. It is useful as a functional food. |
| priorityDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1137.