| abstract |
The present invention discloses a 5-membered heterocyclic amide-based WNT pathway inhibitor belonging to a compound that modulates the Wnt signaling pathway activity, and provides a method for preparing such a compound and its application in the manufacture of drugs that antagonize the Wnt signaling pathway. . The 5-membered heterocyclic amide-based WNT pathway inhibitor provided by the present invention is a target-based rational drug design, has remarkable anti-tumor activity, and can be used for the development of new Wnt pathway inhibitors, and has extremely great clinical application value, The market potential is considerable. |