| abstract |
A genetically modified mouse expressing a human λ variable (hVλ) sequence is provided, and a mouse expressing the hVλ sequence from an endogenous mouse λ light chain locus, a mouse expressing the hVλ sequence from the endogenous mouse κ light chain locus, and a transgene or epi It includes a mouse expressing the hVλ sequence from cotton, wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are sources of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods are provided for producing antigen-binding proteins comprising human λ variable sequences, including human antibodies. |