| abstract |
The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof; Its manufacturing method; Intermediates used in their preparation; Compositions containing the compound or salt; And D3-mediated (or D3-related) disorders such as substance addiction, substance abuse, schizophrenia (e.g., cognitive symptoms thereof), cognitive impairment (e.g. schizophrenia, cognitive impairment associated with AD or PD), Parkinson's disease, cravings, anxiety, impulse control disorders, sexual disorders, and their use for the treatment of depression provide: In the above formula, R 1 , R 2 , R 3 , R 4 , R 5 , a and A are as defined herein. |