| abstract |
A vaccine composition comprising at least one antigen based on dengue virus (DV) capsid protein and an oligonucleotide identified by SEQ ID NO: 1. A vaccine composition comprising the fusion protein produced by the DV2 capsid and domain III of the outer membrane protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO: 1, compared to that produced by the formulation of the same antigen, as reported in the prior art. Together with oligonucleotides with the potential adjuvant capacity, higher levels of cellular immune responses and defenses are generated in mice. The efficacy of compositions comprising the SEQ ID NO: 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, divalent or tetravalent, and are combined into different immune systems in view of eliciting a functional immune response against the four viral serotypes. |