| abstract |
The present invention relates to a method for producing a recombinant acremonium chrysogenum strain producing a high concentration of deacetoxycephalosporin C (DAOC), and to a strain produced by this method, and more particularly, to a high-productivity acremonium chrysose DAOC A method for producing a num strain, a recombinant acremonium chrysogenum strain produced by this method, a DAOC production method in which the strain is cultivated under conditions capable of producing DAOC and recovered, acremonium chrysose used in the production method The present invention relates to a polynucleotide for high DAOC expression in num strain, an expression vector for high DAOC expression in acremonium chrysogenum strain, and a method for producing 7-ADCA by treating the produced DAOC with CPC acylase. According to the present invention, an acremonium chrysogenum strain having high DAOC production ability can be prepared, and by treating DAOC produced by these strains with CPC acylase, 7-ADCA can be produced in an environmentally friendly and efficient manner without toxic by-products. I can. |