http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102185041-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1157 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102185041-B1 |
| titleOfInvention | Three-dimensional in vitro alveolar lung model, method of making the model, and its use to measure and/or predict the sensitizing effect of inhalable products |
| abstract | The present invention relates to a three-dimensional in vitro alveolar lung model essentially comprising the following four cell types: alveolar type II epithelial cells capable of secreting surfactants (stacked in the lungs), providing a permeable barrier Endothelial cells that form the inner lining of capillaries, resin-like cells such as undifferentiated THP-1, which link innate and adaptive immunity, and macrophages that can participate in the defense mechanism by ingesting foreign substances by phagocytosis- Cell-like. The present invention also provides a method for producing the above model, and evaluating the irritation potential or toxicity of inhalable products such as particles or molecules in the alveolar barrier of the lung, and also the sensitizing effect of inhalable products such as particles or molecules in the alveolar barrier of the lung. To measure and/or predict, its use. |
| priorityDate | 2016-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 207.