| abstract |
The invention provided herein relates to compositions, methods, delivery devices and kits for repairing or enlarging tissue in a subject. The compositions described herein are injectable, allowing them to be placed in a tissue to be treated in a minimally-invasive procedure (eg, injection). In some embodiments, the compositions described herein comprise a compressed silk fibroin matrix, which can expand upon injection into the tissue to maintain its original expanded volume within the tissue for a period of time. The composition can be used, for example, as a filler to replace tissue voids for tissue repair and/or enlargement, or as a scaffold to aid in tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or enlargement. |