http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102166867-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 |
| filingDate | 2010-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102166867-B1 |
| titleOfInvention | Compositions and methods for non-toxic delivery of antiprogestins |
| abstract | The subject matter of the present invention is suitable for the field of treating hormone dependent diseases. New compounds and methods for treating these diseases are disclosed. Embodiments of the present invention disclose a method for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation. The present invention is selected from the group including endometritis and related pain, adenomyosis, ovarian endometriosis, menstrual pain, uterine fibroids, endometrial hyperproliferation, ovarian cancer and cervical cancer It is to provide a compound of the following general structural formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, and a method of treating these syndromes effective against the syndrome caused by progesterone. (I) Here, R 1 is alkyl; Alkenyl; Cycloalkyl; Cycloalkenyl; Aryl; H; CH 3 SO; CH 3 SO 2 ; Acyl; Alkoxy; Thioalkoxy; Thioalkyl; Acyloxy; Si(CH 3 ) 3 ; ( ) (Wherein, X and Y are acyl; aziridinyl, azirinyl, azetidinyl, pyrrolidinyl, ethoxypyrrolidinyl, methoxypyrrolidinyl, piperidinyl, ethoxypiperidinyl, morpholinyl, Ethoxymorpholinyl, oxazinyl, piperazinyl, methylpiperazinyl, ethylpiperazinyl and diazinyl; R 2 is hydrogen, halogen, alkyl, acyl, hydroxyl, alkoxy, acyloxy, alkyl carbonate, ci Cypionyloxy, S-alkyl, S-CN, S-acyl and -OC(0)R 6 (Here, R 6 is alkyl, alkoxyalkyl or alkoxy (-OCH 3 ).). R 3 is alkyl, hydroxy, alkoxy and acyloxy. However, R 3 is not acetoxy or propynyl. R 4 is hydrogen or alkyl; X is =0, =N-OR5 (where R5 is hydrogen, alkyl, OH, CH 2 , OAlk 1 and OCOAlk 2 (In which Alk 1 and Alk 2 is a C1-C8 alkyl or aralkyl, C7-C15, single, R 1 is located in the para position, -OCH 3, -SCH 3, -NC 4 H 8, -NC 5 H 10 , -NC 4 H 8 0, -CHO, -CH(OH)CH 3 , -COCH 3 , -0(CH 2 ) 2 NC 4 H 8 ,or -O(CH 2 ) 2 NC 5 H 10 , X is not =0 or =N-OR5 (wherein R5 is hydrogen or alkyl). |
| priorityDate | 2010-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 564.